In order to optimize the synthesis conditions of porous polymers, the amount of two monomers, the amount of crosslink and porogen as the three major influence factors are considered. Simultaneously, response surface methodology is introduced to analysis and predict the optimized conditions using 20-runs CCD. According to the analysis of significant factors of quadratic polynomial model, the amount of three major factors are given (0.47 mL, 1.06 mL and 2.84 mL for MAA, crosslink and porogen; 0.33 mL, 3.45 mL and 3.49 mL for 2-HEMA, crosslink and porogen). The final amount of obtained polymer is verified, and the predicted values corresponded well to actual values.