A true-experimental study was undertaken to assess the Effectiveness of structured teaching programme on prevention of osteoporosis among postmenopausal women in selected rural areas, Guntur, A.P. The Objectives of the study were – 1.To assess the pre and posttest level of knowledge regarding prevention of osteoporosis among postmenopausal women in experimental and control group. 2. To evaluate the effectiveness of structured teaching programme on prevention of osteoporosis among postmenopausal women in experimental group.3To compare the posttest level of knowledge on prevention of osteoporosis among postmenopausal women in experimental and control group.4To find out the association between the post test scores on prevention of osteoporosis and selected demographical variables of postmenopausal women in experimental. The conceptual frame work adopted for the study was based on Dorothy Orem’s supportive educative System Theory. The design adopted for the study was true-experimental with two group pretest and post test design. 60 postmenopausal women were included in this study. Samples were selected by using probability, simple random sampling technique. The structured questionnaire was developed by the investigator to assess the level of knowledge of the postmenopausal women before and after the intervention of structured teaching programme on prevention of osteoporosis. Data collection was done by structured questionnaire. The data was analyzed with the help of descriptive and inferential statistics and findings were interpreted. Data analysis showed that posttest level of knowledge in experimental group 30 postmenopausal women 1(3.34%) were with inadequate knowledge, 6(20%) were with moderately knowledge, 23(76.66%) were with adequate knowledge. The results have shown over all experimental group pretest mean 9.30, standard deviation 3.69, and posttest mean 23.33, standard deviation 4.53, paired ‘t’ test value 23.176. This was significant at p> 0.05 level. Which proved that there was a significant difference between pretest and post test level of knowledge on osteoporosis among menopausal women. Thus research hypothesis is accepted. This indicates that structured teaching programme was effective mainly to improve the knowledge of postmenopausal women regarding prevention of osteoporosis.