Methanol extract of Theobroma cacao was tested for inhibitory activity against Indomethacin and Aspirin induced ulcers. In each ulcer model, twenty male albino rats divided into five groups of four rats each were used for the study. Three out of the five groups of rats received the extract at doses of 100, 200 and 400mg/kg while the other two groups which received 5ml/kg of the extract vehicle (3% Tween 80) and 100mg/kg of ranitidine served as the normal and standard control respectively. The extract doses, Tween 80 and ranitidine were administered to the various rat groups orally. Ulcer was induced in the rats using Indomethacin (50mg/kg) and Aspirin (50mg/kg) 30 minutes after extract administration. The rats were kept under protection for a further 8 hr before being sacrificed by chloroform anesthesia. Their stomachs were isolated, cut along the greater curvature and displayed for ulcer rating on a PVC board. From values of the ulcer index obtained from the ulcer models, the rats pre-treated with the extract showed significant decrease (p<0.05) in ulceration when compared to rats of the normal control (pre-treated with 3% Tween 80) and those of the standard control (pre-treated with ranitidine).